Hereditary Periodic Fever
…-binding-site domain, and a leucine-rich repeat motif region — features that suggest that the protein has an inflammatory role. 76 Children may have a syndrome of periodic fever, aphthous stomatitis, pharyngitis, and tender cervical adenitis. 77 The disorder usually develops before the age of five years…

N Engl J Med 345:1748, December 13, 2001 Review Article

  • Acute Pharyngitis
    …better outcomes in areas where the incidence of acute rheumatic fever is quite low. 19 The development of more sensitive rapid diagnostic assays may render the issue moot. Meanwhile, physicians who elect to use optical immunoassay in children and adolescents without confirmation by culture should do so…

    N Engl J Med 344:205, January 18, 2001 Review Article

  • Analgesics for the Treatment of Pain in Children
    …most widely used antipyretic and mild analgesic for children. The plasma concentrations effective for fever control and analgesia 35 are 10 to 20 μg per milliliter. The recommended oral dosage is 10 to 15 mg per kilogram every four hours for children. Rectal administration produces delayed and variable…

    N Engl J Med 347:1094, October 3, 2002 Review Article

  • Typhoid Fever
    …typhoid fever by Parry et al. largely refers to adults (only 361 of the 3507 patients for whom data are shown in Table 2 are children) and includes a disproportionate number of trials from one country (Vietnam). The majority of cases of typhoid fever in areas where typhoid is endemic occur in children. 1…

    N Engl J Med 348:1182, March 20, 2003 Correspondence

  • Case 18-2001: A 19-Month-Old Boy with Fever and Soft-Tissue Masses
    …a severe or fatal outcome. This group of illnesses includes falciparum malaria, rickettsial diseases, typhoid fever, meningococcemia, hemorrhagic dengue, and other viral hemorrhagic fevers. However, none of these illnesses are associated with lymphadenopathy or arthritis, which was present in the case…

    N Engl J Med 344:1851, June 14, 2001 Case Records of the Massachusetts General Hospital

  • Rheumatic Heart Disease in Developing Countries
    …on rheumatic fever per year from 1967 through 1976, but only 172 per year from 1997 through 2006. Most observers would probably consider this decrease to be a reasonable reflection of the waning incidence of the disease. After all, in the mid-20th century, children with rheumatic fever occupied many…

    N Engl J Med 357:439, August 2, 2007 Perspective

  • Croup
    …Croup (laryngotracheitis and spasmodic croup) is an illness of infants and children younger than 6 years of age, 9 10 with a peak incidence between 7 and 36 months of age. During the second year of life, about 5% of children have croup. The incidence in boys is about 1.5 times that in girls. In a 14…

    N Engl J Med 358:384, January 24, 2008 Clinical Practice

    Related Searches: Croup | Pediatrics | Pneumonia | Epiglottitis

  • Contagious Acute Gastrointestinal Infections
    …contamination. Bacterial Causes Salmonella Because many principles of contagion with respect to enteric organisms were elucidated in studies of typhoid fever, it seems appropriate to begin our discussion of causes of acute gastrointestinal illness with Salmonella typhosa ( S. enterica serotype typhi). Although…

    N Engl J Med 351:2417, December 2, 2004 Review Article

  • Otitis Media
    …more prolonged in children two years of age or younger than in older children in other studies, but antibiotic therapy had a limited effect, reducing the incidence of persistent symptoms by 13 percent on day 4 and shortening the duration of fever by one day. Fifty percent of children have middle-ear fluid…

    N Engl J Med 347:1169, October 10, 2002 Clinical Practice

  • Case 14-1999: A Nine-Year-Old Girl with Fever and Cervical Lymphadenopathy
    …diagnosis of prolonged fever in children has been divided into three major categories: infections, malignant neoplasms, and disorders that are both inflammatory and autoimmune. A specific diagnosis is never made, however, in up to half the cases. 1 2 3 Many infectious agents cause fever and lymphadenopathy…

    N Engl J Med 340:1491, May 13, 1999 Case Records of the Massachusetts General Hospital

  • Randomized Trial of Pulsed Corticosteroid Therapy for Primary Treatment of Kawasaki Disease
    …aspirin, 3 to 5 mg per kilogram daily, until study completion. Children who had a temperature of 38.3°C or higher 36 hours or more after completion of the initial treatment with intravenous immune globulin, without another probable source of fever, were retreated with 2 g of intravenous immune globulin per…

    N Engl J Med 356:663, February 15, 2007 Original Article

  • The Quality of Ambulatory Care Delivered to Children in the United States
    …were obtained for 16.2% of children 3 to 36 months of age who presented with fever of unknown origin and who were thought to be at high risk for sepsis. The reported prevalence of urinary tract infection is high (4 to 5%) among children 2 months to 2 years of age who have fever without an identified source…

    N Engl J Med 357:1515, October 11, 2007 Special Article

  • Sixth Disease and the Ubiquity of Human Herpesviruses
    …(“subitum” meaning “sudden” in Latin). Subsequent reports identified HHV-6 as a major cause of illness in young children who were brought to emergency departments for the evaluation of fever. Depending on the specific age range of the population studied, 10 to 50 percent of febrile illnesses leading to…

    N Engl J Med 352:753, February 24, 2005 Perspective

    Related Searches: Cmv | Ebv | Hhv6 | Roseola

  • Kendig’s Disorders of the Respiratory Tract in Children
    Kendig’s Disorders of the Respiratory Tract in Children was originally published nearly 40 years ago and is now in its seventh edition. In their preface, the editors refer to it as “the bible” of pediatric pulmonology. Although improving on the “bible” may seem sacrilegious, I believe the editors…

    N Engl J Med 355:1402, September 28, 2006 Book Review

  • The Risk of the Hemolytic-Uremic Syndrome after Antibiotic Treatment of Escherichia coli O157:H7 Infections
    …and the presence or absence of bloody diarrhea, caregivers’ reports of fever, and vomiting. Nor was the frequency significantly related to the initial serum urea nitrogen or creatinine concentration or, for the subgroup of children evaluated at Children’s Hospital and Regional Medical Center, the initial…

    N Engl J Med 342:1930, June 29, 2000 Original Article

  • Acute Infectious Diarrhea
    …including those in nursing homes) 7 or rotaviruses (in young children). Since these illnesses are typically short-lived (lasting one to three days) and self-limited, supportive fluid therapy is usually sufficient. Systemic illness, fever, or bloody stools should prompt routine stool testing for salmonella…

    N Engl J Med 350:38, January 1, 2004 Clinical Practice

  • Case 23-1999: A 10-Month-Old Girl with Fever, Upper-Lobe Pneumonia, and a Pleural Effusion
    …recognized to occur worldwide in children of all ethnic groups, although its prevalence remains highest in children of Asian ancestry. 3 The epidemiology of the disease and the occurrence of seasonal epidemics suggest an infectious cause. The clinical features include fever; a polymorphous erythematous rash…

    N Engl J Med 341:353, July 29, 1999 Case Records of the Massachusetts General Hospital

  • Live Attenuated versus Inactivated Influenza Vaccine in Infants and Young Children
    …among young children are similar to those among the elderly, and outpatient visits for confirmed influenza are more frequent among infants and young children than in any other age group. 1 For these reasons, U.S. advisory bodies have recently recommended the routine vaccination of all children 6 to 59 months…

    N Engl J Med 356:685, February 15, 2007 Original Article

  • Imaging Studies after a First Febrile Urinary Tract Infection in Young Children
    …infection in a large cohort of children 1 to 24 months of age. Methods Study Design As part of a multicenter, randomized clinical trial evaluating the efficacy of oral as compared with intravenous antimicrobial agents in children 1 to 24 months of age who had fever, we documented the various imaging…

    N Engl J Med 348:195, January 16, 2003 Original Article

  • Oral versus Intravenous Empirical Antimicrobial Therapy for Fever in Patients with Granulocytopenia Who Are Receiving Cancer Chemotherapy
    …kilogram for children who weighed less than 25 kg), plus intravenous amikacin at a daily dose of 20 mg per kilogram, infused over a period of 30 to 45 minutes. The dose of amikacin was adjusted on the basis of renal function. Assessment and Monitoring All patients were hospitalized until the fever resolved…

    N Engl J Med 341:312, July 29, 1999 Original Article


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